Chlorzoxazone

SKU: orb1307897

Description

Chlorzoxazone is a centrally acting skeletal muscle relaxant used in research to study spasticity and pain models. Its application extends to in vitro investigations of cytochrome P450 2E1 (CYP2E1) activity and in vivo experiments for evaluating myorelaxant effects.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 95-25-0
• MW: 169.57
• Purity: 99.72% (May vary between batches)
• Formula: C₇H₄ClNO₂
• SMILES: ClC1=CC=C2OC(=O)NC2=C1
• Target: Beta Amyloid,FOXO,Cytochromes P450,Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.79 mM);Ethanol:32 mg/mL (188.71 mM);DMSO:45 mg/mL (265.38 mM)

Bioactivity

• In Vivo:
  Chlorzoxazone is a central acting skeletal muscle relaxant that operates by suppressing reflex actions in the spinal column. It is capable of activating rat brain SK2 channel currents within cells. Metabolically, Chlorzoxazone is primarily transformed by CYP2E1 into 6-hydroxychlorzoxazone. Other human liver cytochrome P450 enzymes, such as CYP1A1, CYP1A2, and CYP3A4, may also contribute to its metabolism.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chlorzoxazon, Chlorzoxazone, Cytochrome P450, CYPs, inhibit, Inhibitor, Paraflex, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

2733