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Chlorzoxazone

SKU: orb1307897

Description

Chlorzoxazone is a centrally acting skeletal muscle relaxant used in research to study spasticity and pain models. Its application extends to in vitro investigations of cytochrome P450 2E1 (CYP2E1) activity and in vivo experiments for evaluating myorelaxant effects.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number95-25-0
MW169.57
Purity99.49% (May vary between batches)
FormulaC7H4ClNO2
SMILESClC1=CC=C2OC(=O)NC2=C1
TargetBeta Amyloid,FOXO,Cytochromes P450,Potassium Channel
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.79 mM);Ethanol:32 mg/mL (188.71 mM);DMSO:45 mg/mL (265.38 mM)

Bioactivity

In Vivo
Chlorzoxazone is a central acting skeletal muscle relaxant that operates by suppressing reflex actions in the spinal column. It is capable of activating rat brain SK2 channel currents within cells. Metabolically, Chlorzoxazone is primarily transformed by CYP2E1 into 6-hydroxychlorzoxazone. Other human liver cytochrome P450 enzymes, such as CYP1A1, CYP1A2, and CYP3A4, may also contribute to its metabolism.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chlorzoxazon, Chlorzoxazone, Cytochrome P450, CYPs, inhibit, Inhibitor, Paraflex, Potassium Channel, PotassiumChannel

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 g
$ 70.00
5 g
$ 90.00
10 g
$ 110.00
DispatchUsually dispatched within 3-5 working days
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