Chlortetracycline hydrochloride

SKU: orb1309049

Description

Chlortetracycline hydrochloride is a broad-spectrum tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used in research to study its bacteriostatic effects against various bacteria, Mycoplasma, and Chlamydia in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64-72-2
• MW: 515.35
• Purity: 93.87% (May vary between batches)
• Formula: C₂₂H₂₃ClN₂O₈·HCl
• SMILES: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O)=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O
• Target: ribosome,Parasite,Antibacterial,Antibiotic
• Solubility: DMSO:10 mg/mL (19.4 mM);H2O:10 mg/mL (19.4 mM)

Bioactivity

• In Vivo:
  Chlortetracycline HCl exhibits inhibitory activity against a range of organisms, including Diplococcus pneumoniae (MIC: 0.098 mg/L), Streptococcus pyogenes (MIC: 0.292 mg/L), two strains of Bacillus subtilis (MICs: 0.195 mg/L and 0.15 mg/L), Streptococcus faecalis (MIC: 0.3 mg/L), and Mycobacterium ranae (0.3 mg/L). Its high affinity to a site on the 30S subunit effectively suppresses the activity of various Gram-positive and Gram-negative bacteria, including obligatory anaerobes.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

7-Chlorotetracycline, 7-Chlorotetracycline hydrochloride, 7-Chlorotetracycline Hydrochloride, 30S ribosome, Bacterial, Antibiotic, Chlortetracycline, Chlortetracycline HCl, Chlortetracycline hydrochloride, Chlortetracycline Hydrochloride, Inhibitor, inhibit, Isphamycin

Compound Identifiers

PubChem CID

54682468