Chicoric Acid

SKU: orb1221913

Description

Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.

Key Properties

• CAS Number: 6537-80-0
• MW: 474.37
• Purity: >98% (HPLC)
• Formula: C₂₂H₁₈O₁₂
• SMILES: OC(=O)[C@H](OC(=O)\C=C\c1ccc(O)c(O)c1)[C@@H](OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
• Target: Antibacterial
• Solubility: DMSO : ≥ 347 mg/mL; 731.50 mM

Bioactivity

• In Vivo:
  Animal model: C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days). Dosage: 60 mg/kg. Administration: Drinking water; daily; for 4 weeks. Result: Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion. Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses. Showed a remarkable increase in body weight starting at week 7.
• In Vitro:
  Cell Viability Assay Cell line: 3T3-L1 preadipocytes. Concentration: 10-200 μM. Incubation time: 24, 48, and 72 hours. Result: Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM. Apoptosis Analysis Cell line: 3T3-L1 preadipocytes. Concentration: 100 μM. Incubation time: 48 hours. Result: Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining. Western blot analysis. Cell line: 3T3-L1 preadipocytes. Concentration: 100 μM. Incubation time: 48 hours. Result: Decreased the protein level of p-Akt in a dose- and time-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cichoric acid | Dicaffeoyltartaric acid

Quick Database Links

Gene Symbol

Antibacterial