CFTR corrector 8

SKU: orb1686230

Description

CFTR corrector 8 is a potent small-molecule modulator of the cystic fibrosis transmembrane conductance regulator, designed for cystic fibrosis research. It is utilized in both in vitro and in vivo studies to investigate CFTR protein rescue and function, supporting therapeutic development.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1918142-35-4
• MW: 539.52
• Purity: 99.58%
• Formula: C₂₉H₂₇F₂NO₇
• SMILES: COc1ccc2[C@H](C[C@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
• Target: CFTR
• Solubility: DMSO:10 mg/mL (18.53 mM)

Bioactivity

• In Vitro:
  CFTR corrector 8 demonstrates EC50 values of 1 μM in the CSE-HRP assay and 3 μM in the HBE-TECC assay. CFTR corrector 8 displays a hepatocyte clearance rate of 1250 L/hr/kg in humans and 775 L/hr/kg in rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CFTR

Compound Identifiers

PubChem CID

121301422