CeMMEC13

SKU: orb1225907

Description

A selective TAF1 second bromodomain inhibitor with IC50 of 2.1 uM; shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.

Key Properties

• CAS Number: 1790895-25-8
• MW: 336.3
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₆N₂O₄
• SMILES: O=C(C1=CC(N(C)C2=C1C=CC=C2)=O)NC3=CC=C(OCCO4)C4=C3
• Target: Bromodomain
• Solubility: DMSO: 62 mg/mL (184.3 mM); Ethanol: 6 mg/mL (17.83 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vitro:
  CeMMEC13 is a potent inhibitor of TAF1 (2) bromodomain, with an IC50 of 2.1 μM. CeMMEC13 shows little or no effects on REDNESS, BRD4, CREBBP. CeMMEC13 (0-20 μM) in combination with (S)-JQ1 increases RFP expression in REDS3 cells and is effective reducing the viability of H23 and THP1 cells, better than that of single treatment.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CeMMEC 13

Quick Database Links

Gene Symbol

Bromodomain