Cefodizime

SKU: orb1707475

Description

Cefodizime is a third-generation cephalosporin antibiotic with immunomodulatory properties and low nephrotoxicity. It is utilized in research for studying serious bacterial infections, particularly in the respiratory and urinary tracts, with applications in both in vitro antimicrobial assays and in vivo infection models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 69739-16-8
• MW: 584.67
• Purity: 99.62%
• Formula: C₂₀H₂₀N₆O₇S₄
• SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1CSC=4SC(CC(O)=O)=C(C)N4)[H]
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:40 mg/mL (68.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM)

Bioactivity

• In Vivo:
  Cefodizime exhibits comparable efficacy to Cefotaxime and Ceftazidime, and surpasses Cefoperazone, Latamoxef, Cefuroxime, and Cefazolin in combating K. pneumoniae respiratory tract infections in mice, following a single subcutaneous dose of 50 mg/kg, maintaining significant bactericidal activity up to 48 hours post-administration. This is unlike the aforementioned cephalosporins, as Cefodizime ensures bacterial eradication from the lungs within 48 hours in half of the treated mice, even when no longer present in the serum .
• In Vitro:
  Cefodizime is a bactericidal antibiotic having a high affinity for penicillin-binding proteins lA/B, 2, and 3 of E. coli. Cefodizime inhibits other Gram-negative bacteria including Haemophilus irifluenzae, Neisseria gonorrhoeae, Moraxella catarrhalis, and Neisseria meningitidis. Cefodizime has marginal but variable inhibitory activity against Citrobacter species including Serratia marcescens and Citrobacter freundii. The in vitro concentrations of Cefodizime resulting in bactericidal activity against susceptible strains of Gram-positive and Gram-negative bacteria are generally similar to the minimum inhibitory concentrations .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Bacterial, Cefodizime

Compound Identifiers

PubChem CID

5361871