Caspofungin Acetate

SKU: orb1307417

Description

Caspofungin Acetate (MK-0991) is a semisynthetic echinocandin antifungal agent derived from Glarea lozoyensis. It is used in research to study its potent in vitro and in vivo activity against Aspergillus and Candida species, primarily by inhibiting beta-(1,3)-D-glucan synthesis in fungal cell walls.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 179463-17-3
• MW: 1213.42
• Purity: 99.90%
• Formula: C₅₆H₉₆N₁₀O₁₉
• SMILES: CC(O)=O.CC(O)=O.CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@@H](O)[C@H](O)c1ccc(O)cc1)[C@H](O)CCN
• Target: Antibiotic,Antifungal,Antibacterial
• Solubility: DMSO:102 mg/mL (84.06 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (2.72 mM);H2O:100 mg/mL (82.41 mM)

Bioactivity

• In Vivo:
  Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM cause no significant alterations in their ERG waveforms and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively.
• In Vitro:
  Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caspofungin Acetate, Caspofungin diacetate, Cancidas, Antibiotic, antifungal, 1,3-beta-D-glucan synthesis, L743872, L-743872, L-743872 diacetate, L743873, L-743873, Fungal, fungal cell wall, Inhibitor, L 743872, L 743873, inhibit, MK0991, MK-0991, MK-0991 diacetate, MK 0991

Compound Identifiers

PubChem CID

66577041