Caspofungin acetate

SKU: orb1225900

Description

A lipopeptide antifungal agent that works by inhibiting the enzyme 1,3-beta-glucan synthase and thereby disturbing the integrity of the fungal cell wall.Fungal Infection Approved(In Vitro):Caspofungin diacetate (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain.Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice.

Key Properties

• CAS Number: 179463-17-3
• MW: 1213.417
• Purity: >98% (HPLC)
• Formula: C₅₆H₉₆N₁₀O₁₉
• SMILES: CC(O)=O.CC(O)=O.CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(O)C(NCCN)NC(=O)C2C(O)CCN2C(=O)C(NC(=O)C(NC(=O)C2CC(O)CN2C(=O)C(NC1=O)C(C)O)C(O)C(O)C1=CC=C(O)C=C1)C(O)CCN
• Target: Fungal
• Solubility: H2O: ≥ 100 mg/mL

Bioactivity

• In Vivo:
  Animal model: Complement component 5-deficient DBA/2N mice. Dosage: 1, 2, 4 and 8 mg/kg. Administration: Intraperitoneal injection; daily, for 7 days. Result: Reduced the concentration of Candida load in the brain. Animal model: Male C57BL/6 mice. Dosage: 0.41, 1.2, 2.5, 4.1, and 41 μM. Administration: Intraperitoneal injection; for 5 weeks. Result: Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L-743872 | L-743873 | MK-0991

Quick Database Links

Gene Symbol

Fungal