BVDV-IN-1

SKU: orb1298368

Description

BVDV-IN-1 is a potent non-nucleoside inhibitor of the bovine viral diarrhea virus (BVDV) RNA-dependent RNA polymerase (RdRp), exhibiting antiviral activity with an EC50 of 1.8 µM. It binds a hydrophobic pocket on the RdRp and retains efficacy against strains resistant to thiosemicarbazone-class NNIs, making it a valuable tool for antiviral mechanism and resistance studies.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 345651-04-9
• MW: 334.41
• Purity: 98.93% (May vary between batches)
• Formula: C₂₀H₂₂N₄O
• SMILES: OCCN1CCN(CC1)c1nc(nc2ccccc12)-c1ccccc1
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.95 mM);DMSO:250 mg/mL (747.59 mM)

Bioactivity

• In Vitro:
  BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC). It is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bovine, BVDV IN 1, BVDVIN1, BVDV-IN-1, antiviral, activity, diarrhea, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, inhibitor, non-nucleoside, inhibit, RNASynthesis, RNA Synthesis, virus, viral

Compound Identifiers

PubChem CID

12796039