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BVDV-IN-1

SKU: orb1218131

Description

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).

Images & Validation

Key Properties

CAS Number345651-04-9
MW334.42
Purity>98% (HPLC)
FormulaC20H22N4O
SMILESOCCN1CCN(C2=C3C=CC=CC3=NC(C4=CC=CC=C4)=N2)CC1
TargetDNA/RNA Synthesis
SolubilityDMSO : 250 mg/mL (747.59 mM; Need ultrasonic)

Bioactivity

In Vitro
BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp). BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • BVDV-IN-1 [orb1298368]

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    345651-04-9

    334.41

    C20H22N4O

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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5 mg
$ 230.00
10 mg
$ 360.00
25 mg
$ 700.00
50 mg
$ 1,030.00
100 mg
$ 1,450.00
500 mg
$ 2,880.00