Bupivacaine hydrochloride

SKU: orb1225892

Description

Bupivacaine hydrochloride binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias. Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.(In Vitro):Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization.Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM.Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 μM.

Key Properties

• CAS Number: 18010-40-7
• MW: 324.89
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₈N₂O·HCl
• SMILES: Cl.CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
• Target: Prostaglandin Receptor
• Solubility: Ethanol: 65 mg/mL (200.06 mM); Water: 23 mg/mL (70.79 mM); DMSO: 65 mg/mL (200.06 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Prostaglandin Receptor