Bromfenac Sodium

SKU: orb1300781

Description

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2) to block prostaglandin synthesis. It is used in research for studying inflammation and pain mechanisms in both in vitro enzyme assays and in vivo animal models of ocular inflammation and postoperative pain.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 91714-93-1
• MW: 356.15
• Purity: 99.22% (May vary between batches)
• Formula: C₁₅H₁₁BrNO₃·Na
• SMILES: [Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C1=CC=C(Br)C=C1
• Target: COX
• Solubility: DMSO:55 mg/mL (154.43 mM);Ethanol:2 mg/mL (5.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.81 mM);H2O:65 mg/mL (182.51 mM)

Bioactivity

• Target IC50:
  COX-2:7.45 nM (IC50)|COX-1:5.56 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX, COX-1, COX-2, Cyclooxygenase, Bronuck, Bromfenac, Bromfenac Sodium, AHR 10282B, AHR 10282R, HLEC-B3, inhibit, Inhibitor, ocular inflammation

Compound Identifiers

PubChem CID

23693301