Bromfenac sodium hydrate

SKU: orb1703475

Description

Bromfenac sodium hydrate is a COX-II inhibiting NSAID used in ophthalmic research for its anti-inflammatory and analgesic properties. It is applied in models of ocular inflammation, such as post-cataract surgery studies, to investigate prostaglandin-mediated pathways and their effects on intraocular pressure and blood-aqueous barrier integrity.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120638-55-3
• MW: 383.17
• Purity: 99.65% (May vary between batches)
• Formula: C₁₅H₁₂BrNO₃·3/2H₂O·Na
• SMILES: O.[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c1ccc(Br)cc1
• Target: COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM);DMSO:12.5 mg/mL (32.62 mM)

Bioactivity

• Target IC50:
  COX-1:5.56 nM (IC50)|COX-2:7.45 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bromfenac monosodium salt sesquihydrate, Bromfenac monosodium sesquihydrate, Bromfenac sodium, Bromfenac sodium sesquihydrate, COX, COX-2, HLEC-B3, ocular inflammation

Compound Identifiers

PubChem CID

23663409