Brivudine

SKU: orb1310353

Description

Brivudine

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 69304-47-8
• MW: 333.14
• Purity: 99.85%
• Formula: C₁₁H₁₃BrN₂O₅
• SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cc(\C=C\Br)c(=O)[nH]c1=O
• Target: HSV,Virus Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (30.02 mM);DMSO:50 mg/mL (150.09 mM)

Bioactivity

• In Vivo:
  At a dose of 12 mg once daily, brivudine has been shown to be superior to aciclovir with respect to reducin the period of new blister production and shortenin the duration of post-herpetic neuralgi.
• In Vitro:
  Brivudine is an analog of thymidine, and is incorporated int the viral DNA. It block the action of DNA polymerases thereby inhibiting viral replication. It has a stronger antiviral effect agains the varicella-zoster virus than reference compounds such as aciclovir or penciclovi. It has high, Selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive Inhibition of viral DNA polymerase, or by acting as an alternative substratee to deoxythymidine triphosphate, causing viral DNA st and breakag.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CMV, Brivudine, Cytomegalovirus, Bromovinyldeoxyuridine, BVDU, HSV-1, Inhibitor, inhibit, VZV

Compound Identifiers

PubChem CID

446727