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Brivudine monophosphate
Catalog Number: orb1740824
| Catalog Number | orb1740824 |
|---|---|
| Category | Small Molecules |
| Description | Brivudine monophosphate |
| CAS Number | 80860-82-8 |
| Purity | 0.98 |
| MW | 413.12 |
| SMILES | O=C1N(C=C(/C=C/Br)C(=O)N1)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)C2 |
| Formula | C11H14BrN2O8P |
| Biological Activity | Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
