Boc-NH-PEG7-NH2

SKU: orb1308532

Description

Boc-NH-PEG7-NH2 is a heterobifunctional polyethylene glycol (PEG) spacer commonly employed in PROTAC development. Its structure facilitates the conjugation of a target-binding ligand to an E3 ubiquitin ligase recruiter, enabling the study of targeted protein degradation in both cellular and biochemical assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 206265-98-7
• MW: 468.58
• Purity: 98.47%
• Formula: C₂₁H₄₄N₂O₉
• SMILES: C(OCCOCCOCCOCCOCCOCCOCCN)CNC(OC(C)(C)C)=O
• Target: PROTAC Linker
• Solubility: DMSO:250 mg/mL (533.53 mM)

Bioactivity

• In Vitro:
  PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Boc NH PEG7 NH2, BocNHPEG7NH2, Boc-NH-PEG-7-NH2, Boc-NH-PEG7-NH2, Alkyl/ether, inhibit, Inhibitor, PEGs, PROTACLinker, PROTAC Linker, PROTAC Linkers

Compound Identifiers

PubChem CID

5214899