Boc-NH-PEG3-NHS ester

SKU: orb1307492

Description

Boc-NH-PEG3-NHS ester is a heterobifunctional PROTAC linker featuring a cleavable Boc-protected amine and an NHS ester for conjugation. This PEG-based spacer is widely used in synthesizing proteolysis-targeting chimeras (PROTACs) for both in vitro and in vivo targeted protein degradation research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2250216-93-2
• MW: 418.44
• Purity: 99.74% (May vary between batches)
• Formula: C₁₈H₃₀N₂O₉
• SMILES: O(C(CCOCCOCCOCCNC(OC(C)(C)C)=O)=O)N1C(=O)CCC1=O
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs, which contain two distinct ligands connected by a linker—one for an E3 ubiquitin ligase and the other for the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, PEGs, Inhibitor, Boc NH PEG3 NHS ester, BocNHPEG3NHS ester, Boc-NH-PEG-3-NHS ester, Boc-NH-PEG3-NHS ester, PROTAC Linker, PROTAC Linkers, PROTACLinker

Compound Identifiers

PubChem CID

134827758