Boc-NH-PEG3-CH2COOH

SKU: orb1308535

Description

Boc-NH-PEG3-CH2COOH is a heterobifunctional linker utilized in constructing PROTAC molecules for targeted protein degradation research. Its PEG spacer and terminal carboxyl group enable conjugation to warheads and E3 ligands, facilitating the development of degraders for in vitro and in vivo biological studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 462100-06-7
• MW: 307.34
• Purity: ≥98% (May vary between batches)
• Formula: C₁₃H₂₅NO₇
• SMILES: O(C(NCCOCCOCCOCC(O)=O)=O)C(C)(C)C
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase, while the other binds to the target protein. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Boc NH PEG3 CH2COOH, BocNHPEG3CH2COOH, Boc-NH-PEG-3-CH2COOH, Boc-NH-PEG3-CH2COOH, Alkyl/ether, Inhibitor, inhibit, PEGs, PROTAC Linkers, PROTACLinker, PROTAC Linker

Compound Identifiers

PubChem CID

15544433