Boc-NH-O-C1-NHS ester

SKU: orb1307500

Description

Boc-NH-O-C1-NHS ester is an alkyl/ether linker used in constructing PROTAC molecules for targeted protein degradation. This reagent is applicable in both in vitro biochemical assays and in vivo research to develop novel therapeutic strategies across oncology and disease biology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 80366-85-4
• MW: 288.25
• Purity: ≥98% (May vary between batches)
• Formula: C₁₁H₁₆N₂O₇
• SMILES: CC(C)(C)OC(=O)NOCC(=O)ON1C(=O)CCC1=O
• Target: PROTAC Linker
• Solubility: DMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.94 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands connected by a linker; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alkyl/ether, BocNHOC1NHS ester, Boc-NH-O-C-1-NHS ester, Boc-NH-O-C1-NHS ester, Boc NH O C1 NHS ester, inhibit, Inhibitor, PROTAC Linker, PROTAC Linkers, PROTACLinker

Compound Identifiers

PubChem CID

12098210