Bindarit

SKU: orb1226582

Description

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.(In Vitro):Bindarit (10-300 μM; 48 hours) at 100 μM and 300 μM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively.(In Vivo):Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation.

Key Properties

• CAS Number: 130641-38-2
• MW: 324.37
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₀N₂O₃
• SMILES: CC(C)(OCC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O
• Target: CCR
• Solubility: DMSO:65 mg/mL (200.38 mM); Ethanol:65 mg/mL (200.38 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Animal model: NZB/W F1 female mice (two months of age). Dosage: 50 mg/kg. Administration: Oral administration; every day; for 4 months, 6 months, 8 months. Result: Delayed the onset of proteinuria and significantly protected from renal function impairment.
• In Vitro:
  Cell Viability Assay Cell line: VSMC cells. Concentration: 10 μM, 30 μM, 100 μM, 300 μM. Incubation time: 48 hours. Result: Inhibited PDGF-BB-induced rat VSMCs proliferation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AF 2838

Quick Database Links

Gene Symbol

CCR