Bindarit

SKU: orb1300789

Description

Bindarit

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130641-38-2
• MW: 324.37
• Purity: 98.35%
• Formula: C₁₉H₂₀N₂O₃
• SMILES: CC(C)(OCc1nn(Cc2ccccc2)c2ccccc12)C(O)=O
• Target: CCR
• Solubility: DMSO:45 mg/mL (138.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.17 mM);Ethanol:25 mg/mL (77.07 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  CCL2:403 µM|MCP-1:172 µM
• In Vivo:
  METHODS: Bindarit (AF2838) (200 μg/g) was used to treat the OVX mouse model to verify the expression of CCL2 and CCL7. RESULTS Bindarit attenuated the expression of CCL2 and CCL7 in the OVX mouse model.
• In Vitro:
  METHODS: Raw 264.7 cells were stimulated with LPS (1 μg/ml) at different time points (1, 2, 4, 8, and 24 h) with bindarit (AF2838) (300 μM, 1 h before treatment) to investigate the mechanism by which bindarit exerts its anti-inflammatory effects. RESULTS Bindarit pretreatment significantly reduced MCP-1 mRNA levels, and at the highest LPS-induced peak (4 h), MCP-2 and MCP-3 gene expressions were inhibited by 24% and 36%, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCR, Bindarit, AF2838, AF-2838, AF 2838, CC chemokine receptor, Inhibitor, MCP-1/CCL2, MCP-3/CCL7, MCP-2/CCL8, inhibit

Compound Identifiers

PubChem CID

71354