Bilirubin

SKU: orb1304828

Description

Bilirubin

Research Area

Metabolism Research

Key Properties

• CAS Number: 635-65-4
• MW: 584.66
• Purity: 99.59%
• Formula: C₃₃H₃₆N₄O₆
• SMILES: C(C1=C(CCC(O)=O)C(C)=C(/C=C\2/C(C=C)=C(C)C(=O)N2)N1)C3=C(CCC(O)=O)C(C)=C(/C=C\4/C(C)=C(C=C)C(=O)N4)N3
• Target: Endogenous Metabolite
• Solubility: DMSO:9 mg/mL (15.39 mM)

Bioactivity

• In Vivo:
  METHODS: To investigate the effects on atherosclerosis, Bilirubin (30 mg/kg, 50 mmol/L of K3PO4 plus 10% serum) was administered intraperitoneally to Ldlr-/- mice on Western diet once daily for eight weeks. RESULTS: Bilirubin prevented atherosclerotic plaque formation but did not alter circulating cholesterol or chemokine levels. Bilirubin-treated animals had reduced lipid and collagen deposition in the aortic root, decreased monocyte and lymphocyte infiltration, fewer smooth muscle cells, decreased levels of chlorotyrosine and nitrotyrosine, and no changes in VCAM-1 or ICAM-1 expression.
• In Vitro:
  METHODS: Hippocampal primary neurons were treated with Bilirubin (12-25 µM) for 24 h. Mitochondrial membrane potential (ΔΨm) was measured by JC-1 fluorescence staining. RESULTS: Bilirubin treatment decreased ΔΨm in a dose-dependent manner. METHODS: Neural stem cell NSC were treated with Bilirubin (6.25-50 µM) for 96 h. Cell viability was measured by MTT assay. RESULTS: Cell viability was significantly reduced after exposure to 50 µM Bilirubin concentration. The viability of cells exposed to Bilirubin was gradually and significantly reduced.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Principal bile pigment, Inhibitor, Hematoidin, heme, Hemetoidin, EndogenousMetabolite, Endogenous Metabolite, inhibit, Bilibubin, Bilirubin, antimutagenic, antioxidant, catabolism

Compound Identifiers

PubChem CID

5280352