B355252

SKU: orb1298567

Description

B355252

Research Area

Cell Biology

Key Properties

• CAS Number: 1261576-81-1
• MW: 514.06
• Purity: 98.73% (May vary between batches)
• Formula: C₂₅H₂₄ClN₃O₃S₂
• SMILES: Clc1cc(sc1Oc1cccc(c1)N1CCNCC1)S(=O)(=O)NCc1cccc2ccccc12
• Target: Others,Apoptosis
• Solubility: DMSO:25 mg/mL (48.63 mM)

Bioactivity

• In Vitro:
  Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B355252, B-355252, B 355252, Apoptosis, DNA damage, Parkinson disease, NGF, neurite outgrowth, inhibit, ischemic neurons, LDH level, Inhibitor, glutamate, HT22, phenoxy thiophene sulfonamide, ROS production

Compound Identifiers

PubChem CID

52912652