Aztreonam

SKU: orb1310009

Description

Aztreonam (SQ-26,776) is a bactericidal, monocyclic beta-lactam antibiotic derived from Chromobacterium violaceum. It is widely used in research for studying Gram-negative bacterial infections, serving as a key tool for in vitro susceptibility testing and in vivo infection model studies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 78110-38-0
• MW: 435.43
• Purity: 97.60% (May vary between batches)
• Formula: C₁₃H₁₇N₅O₈S₂
• SMILES: C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\c2csc(N)n2)C(=O)N1S(O)(=O)=O
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:148 mg/mL (339.89 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:9 mg/mL (20.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.19 mM)

Bioactivity

• In Vivo:
  Aztreonam (300 mg/kg) results in a significant decrease in the content of hepatic microsomal P450, while no significant change is observed in hepatic cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity.
• In Vitro:
  Aztreonam causes significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations in human bone marrow cells. Aztreonam is hydrolyzed at measurable rates by class A beta-lactamases, a TEM-2 type penicillinase and the Proteus vulgaris cephalosporinase with a broad substraterange. Aztreonam is extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acts as a competitive and progressive inhibitor for the beta-lactamase. Aztreonam (AZT) combined with clindamycin (CLDM) has synergistic effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Haemophilus influenzae, which are sensitive or quasi-sensitive to CLDM, in the presence of CLDM at MIC or sub-MIC. Aztreonam reduces the cfu of some strains by 1 log unit without preserving the integrity of cystic fibrosis airway cell monolayers, while decreasing the biofilms of other clinical isolates by 4 log units and protecting the monolayers from being compromised.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Aztreonam, Antibiotic, PBPs, inhibit, Inhibitor, SQ-26,776, β-Lactamase

Compound Identifiers

PubChem CID

5742832