Tigemonam

SKU: orb1707797

Description

Tigemonam is a novel, orally bioavailable monobactam antibiotic. It exhibits potent activity against Gram-negative aerobic bacteria, with in vitro efficacy against Enterobacteriaceae comparable to agents like aztreonam. This profile supports its research in antimicrobial development and in vivo infection models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 102507-71-1
• MW: 437.41
• Purity: >99.99% (May vary between batches)
• Formula: C₁₂H₁₅N₅O₉S₂
• SMILES: N(C(/C(=N\OCC(O)=O)/C=1N=C(N)SC1)=O)[C@H]2C(C)(C)N(OS(=O)(=O)O)C2=O
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:55 mg/mL (125.74 mM)

Bioactivity

• In Vivo:
  Tigemonam demonstrates potent efficacy against a range of bacterial strains, including E. coli SC 12199, Escherichia coli SC 8294, Salmonella schottmulleri SC 3850, Proteus mirabilis SC 9575, Providencia rettgeri SC 8217, Klebsiella pneumoniae SC 12216, Serratia marcescens SC 9782, Enterobacter cloacae SC 11078, and Haemophilus influenzae SC 10556, achieving ED50 values of 1.5 mg/kg, 1.4 mg/kg, 0.7 mg/kg, 0.3 mg/kg, 0.2 mg/kg, 0.9 mg/kg, 0.5 mg/kg, 3.9 mg/kg, and 1.8 mg/kg respectively in mice.
• In Vitro:
  Tigemonam (0.25 mg/L) inhibits 90% of Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Haemophilus influenzae, and Branhamella catarrhalis. The MIC90 is 16 mg/L for Enterobacter spp. and 4 mg/L for Citrobacter. Pseudomonas aeruginosa is resistant to tigemonam but susceptible to aztreonam. Tigemonam shows minimal inoculum dependence, between 10^2 and 10^6 cfu per spot .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tigemonam

Compound Identifiers

PubChem CID

9576769