Azimilide dihydrochloride

SKU: orb1226180

Description

A class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively; blocks the rapidly activating component of the delayed rectifier, IKr (IC50=0.4 uM), and inhibits IKs (IC50=3 uM); shows anti-arrhythmic effects.Heart Arrhythmia Phase 3 Clinical.

Key Properties

• CAS Number: 149888-94-8
• MW: 530.875
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₀Cl₃N₅O₃
• SMILES: CN1CCN(CC1)CCCCN2C(=O)CN(C2=O)N=CC3=CC=C(O3)C4=CC=C(C=C4)Cl.Cl.Cl
• Target: Potassium Channel
• Solubility: DMSO: < 10.4 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NE-10064 dihydrochloride

Quick Database Links

Gene Symbol

Potassium Channel