AZD3229

SKU: orb1301814

Description

AZD3229 is a highly effective small molecule inhibitor targeting diverse KIT mutations, demonstrating potent anti-proliferative activity in the low nanomolar range against gastrointestinal stromal tumor (GIST) cell lines. It is a valuable research tool for investigating KIT-driven oncogenesis in both in vitro and in vivo preclinical models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2248003-60-1
• MW: 479.51
• Purity: 98.83% (May vary between batches)
• Formula: C₂₄H₂₆FN₇O₃
• SMILES: COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(nn4)C(C)C)cc3)ncnc2c1
• Target: c-Kit
• Solubility: H2O:Insoluble;DMSO:95 mg/mL (198.12 mM);10% DMSO+90% Corn Oil:5 mg/mL (10.43 mM)

Bioactivity

• In Vivo:
  Following a single dose (AZD3229, 20 mg/kg), high free cover over the target is achieved and is associated with complete suppression of pKIT and downstream markers out to 8 hours. As the compound is cleared and cover declines, these signals recover although recovery is not complete even at 24 hours.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Kit, AZD 3229, AZD3229, AZD-3229, CD117, cKit, c-Kit, SCFR

Compound Identifiers

PubChem CID

134814269