AZD-7648

SKU: orb1300051

Description

AZD-7648 is a potent and selective DNA-PK inhibitor with an enzyme assay IC50 of 0.63 nM. It is a research tool for studying DNA damage response and has demonstrated antitumor efficacy in preclinical in vitro and in vivo models.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2230820-11-6
• MW: 380.4
• Purity: 99.85% (May vary between batches)
• Formula: C₁₈H₂₀N₈O₂
• SMILES: Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
• Target: PI3K,Apoptosis,ATM/ATR,DNA-PK
• Solubility: DMSO:9.52 mg/mL (25.03 mM)

Bioactivity

• Target IC50:
  DNA-PK:0.63 nM|PI3Kγ:1.37 μM|ATM:17.93 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA-dependent protein kinase, DNAPK, DNA-PK, AZD 7648, ATM/ATR, ATM and RAD3 related, Ataxia telangiectasia mutated, AZD7648, AZD-7648, antitumor, Apoptosis, A549, Inhibitor, OAW42, inhibit, PI3K, Phosphoinositide 3-kinase

Compound Identifiers

PubChem CID

135151360