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AZD-7648

SKU: orb1220514

Description

AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assayhas anti-tumor activity.(In Vitro):AZD7648 (0-30 μM) is a potent radiosensitizer.AZD7648 (3 μM) increases sensitivity to doxorubicin.AZD7648 (0.6 μM) enhances the activity of PARP inhibitor olaparib.(In Vivo):AZD-7648 (100 mg/kg; p.o.; once daily for 5 days) induces tumour growth inhibition and tumour regression.

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Key Properties

CAS Number2230820-11-6
MW380.4
Purity>98% (HPLC)
FormulaC18H20N8O2
SMILESCc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1
TargetDNA-PK
SolubilityDMSO:5 mg/mL (13.14 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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AZD-7648 (orb1220514)

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Available Sizes

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200 mg
500 mg
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 260.00
50 mg
$ 410.00
100 mg
$ 610.00