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Catalog Number | orb180467 |
---|---|
Category | Antibodies |
Description | Goat polyclonal antibody to ATXN3. This protein appears to be a component of the ubiquitin proteasome system and has deubiquitinase activity. It may also have roles in neuroprotection, protein homeostasis maintenance, transcriptional and cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. The protein contains Qn repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease also known as spinocerebellar ataxia-3, an autosomal dominant neurologic disorder. |
Species/Host | Goat |
Clonality | Polyclonal |
Tested applications | WB |
Reactivity | Bovine, Canine, Donkey, Equine, Feline, Gallus, Goat, Guinea pig, Hamster, Human, Mouse, Other, Porcine, Primate, Rabbit, Rat, Sheep |
Isotype | IgG |
Immunogen | Purified recombinant peptide derived from within residues 120 aa to 250 aa of human ATXN3 produced in E. coli. |
Concentration | 3 mg/ml |
Dilution range | WB:1:250-1:2,000 |
Form/Appearance | Polyclonal antibody supplied as a 200 or 500 µl (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum. |
Conjugation | Unconjugated |
Target | ATXN3 |
Storage | Store at -20°C for long-term storage. Store at 2-8°C for up to one month. |
Buffer/Preservatives | PBS, 20% glycerol and 0.05% sodium azide |
Alternative names | AT3, ATX3, ataxin-3, ataxin 3 variant h, autosomal Read more... |
Note | For research use only |
Application notes | The antibody solution should be gently mixed before use. |
Expiration Date | 12 months from date of receipt. |
Western blot analysis of SH-SY5Y cell line lysate using ATXN3 antibody.
FC, ICC, IF, IHC, WB | |
Bovine | |
Human, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
IF, IH, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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