Atomoxetine hydrochloride

SKU: orb1310216

Description

Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used in research to study cognitive function. It is widely applied in neuroscience for investigating attention and impulse control mechanisms in both in vitro transporter assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 82248-59-7
• MW: 291.82
• Purity: 99.80% (May vary between batches)
• Formula: C₁₇H₂₂ClNO
• SMILES: Cl.CNCC[C@@H](Oc1ccccc1C)c1ccccc1
• Target: 5-HT Receptor,Sodium Channel,Dopamine Receptor,Adrenergic Receptor,Serotonin Transporter,Norepinephrine
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.85 mM);H2O:6.9 mM;DMSO:50 mg/mL (171.34 mM)

Bioactivity

• Target IC50:
  Dopamine transporter:1451 nM(Ki)|NET:5 nM(Ki)|5-HT:77 nM(Ki)
• In Vivo:
  Atomoxetine is a selective inhibitor of norepinephrine reuptake (Ki: 5 nM) and relatively unselective for 5-hydroxytryptamine (Ki: 77 nM) and dopamine transporter protein (Ki: 1451 nM).
• In Vitro:
  Atomoxetine selectively inhibited the presynaptic uptake of norepinephrine by adrenergic neurons in animals and was also active in an animal model of depression. In microdialysis studies, Atomoxetine had no effect on 5-HTEX levels but increased extracellular norepinephrine levels in the prefrontal cortex by 3-fold. Atomoxetine did not alter DAEX and Fos in the nucleus ambiguus and striatum, but increased DAEX concentrations in the PFC by 3-fold and Fos by 3.7-fold.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tomoxetine, Tomoxetine hydrochloride, Dopamine Receptor, DopamineReceptor, DA transporter, (R)-Tomoxetine, (R)-Tomoxetine hydrochloride, 5-HT, 5HTReceptor, 5HT Receptor, Atomoxetine HCl, Atomoxetine, LY139603, LY-139603, LY 139603 HCl, Norepinephrine (NE) transporter

Compound Identifiers

PubChem CID

54840