Atomoxetine hydrochloride

SKU: orb1310216

Description

Atomoxetine hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 82248-59-7
• MW: 291.82
• Purity: 99.8%
• Formula: C₁₇H₂₂ClNO
• SMILES: Cl.CNCC[C@@H](Oc1ccccc1C)c1ccccc1
• Target: Dopamine Receptor,Sodium Channel,Adrenergic Receptor,5-HT Receptor,Norepinephrine,Serotonin Transporter
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.85 mM);H2O:6.9 mM;DMSO:50 mg/mL (171.34 mM)

Bioactivity

• Target IC50:
  Dopamine transporter:1451 nM(Ki)|NET:5 nM(Ki)|5 hT:77 nM(Ki)
• In Vivo:
  Atomoxetine is a Selective inhibitor of norepinephrine reuptake (Ki: 5 nM) and relatively u Selective for 5 hydroxytryptamine (Ki: 77 nM) and dopamine transporter protein (Ki: 1451 nM).
• In Vitro:
  Atomoxetine selectively inhibite the presynaptic uptake of norepinephrine by adrenergic neurons in animals and was also active in an animal model of depression. In microdialysis studies, Atomoxetine had no effect on 5 hTEX levels but increased extracellular norepinephrine levels in the prefrontal cortex by 3-fold. Atomoxetine did not alter DAEX and Fos in the nucleus ambiguus and striatum, but increased DAEX concentration in the PFC by 3-fold and Fos by 3.7-fold.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tomoxetine, Tomoxetine hydrochloride, Dopamine Receptor, DopamineReceptor, DA transporter, (R)-Tomoxetine, (R)-Tomoxetine hydrochloride, 5-HT, 5HTReceptor, 5HT Receptor, Atomoxetine HCl, Atomoxetine, LY139603, LY-139603, LY 139603 HCl, Norepinephrine (NE) transporter

Compound Identifiers

PubChem CID

54840