Atomoxetine hydrochloride

SKU: orb1223935

Description

A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM; shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively; approved for the treatment of attention deficit hyperactivity disorder (ADHD).Other Indication Approved.

Key Properties

• CAS Number: 82248-59-7
• MW: 291.8157
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₂ClNO
• SMILES: CC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.[H]Cl
• Target: Monoamine Transporter
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats. Dosage: 0.3, 1 and 3 mg/kg. Administration: Intraperitoneal injection; for 4 hours. Result: Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold. Animal model: Spontaneously hypertensive rat (SHR). Dosage: 0.1, 0.3, 1.25 and 5.0 mg/kg. Administration: Intraperitoneal injection and oral administration; for 14 days. Result: Had non-impact on the measurement of motor activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tomoxetine | LY-139603

Quick Database Links

Gene Symbol

Monoamine Transporter