AT-007

SKU: orb1309970

Description

AT-007 is a potent, brain-penetrant Aldose Reductase inhibitor (IC50: 100 pM) for research into Galactosemia. It effectively lowers galactitol in models of GALT deficiency and is used in vitro and in vivo to study disease mechanisms and potential therapeutic interventions.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2170729-29-8
• MW: 425.4
• Purity: 99.36%
• Formula: C₁₇H₁₀F₃N₃O₃S₂
• SMILES: OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2cscc12
• Target: Reductase
• Solubility: DMSO:35.71 mg/mL (83.94 mM)

Bioactivity

• Target IC50:
  Aldose reductase:100 pM
• In Vivo:
  AT-007 markedly reduces galactitol levels across all target tissues (liver, brain, and plasma) in GALT null rats, without elevating galactose or Gal-1P concentrations .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, AT 007, AT007, AT-007, Aldose Reductase

Compound Identifiers

PubChem CID

132260161