Apicidin

SKU: orb2655817

Description

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay; induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin; upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.

Key Properties

• CAS Number: 183506-66-3
• MW: 623.78
• Purity: >98% (HPLC)
• Formula: C₃₄H₄₉N₅O₆
• SMILES: O=C(N[C@@H](CCCCCC(CC)=O)C(N[C@@H](CC(N1OC)=CC2=C1C=CC=C2)C(N[C@H]3[C@H](C)CC)=O)=O)[C@](CCCC4)([H])N4C3=O
• Target: HDAC
• Solubility: In Vitro: DMSO : 25 mg/mL (40.08 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OSI 2040

Quick Database Links

Gene Symbol

HDAC