Anticancer agent 73

SKU: orb1689602

Description

Anticancer agent 73

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 124811-87-6
• MW: 261.27
• Purity: 99.19% (May vary between batches)
• Formula: C₁₄H₁₅NO₄
• SMILES: CCOC(=O)c1nc(oc1C)-c1ccc(OC)cc1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:90 mg/mL (344.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.63 mM)

Bioactivity

• In Vivo:
  Anticancer agent 73 (compound CIB-3b) (10, 25, and 50 mg/kg; i.v.; every 2 days for 4 weeks; SCID mice) diminishes the proliferation and migration of both SK-HEP-1 cells and SK-HEP-1 cells implanted in SCID mice.
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• In Vitro:
  Anticancer agent 73 (compound CIB-3b) (10 μM; 6 h) elevates E-cadherin expression and reduces fibronectin, N-cadherin, and vimentin protein levels in SK-HEP-1 cells. It also inhibits the proliferation and migration of SK-HEP-1, HCCLM3, and MHCC97L cells by impeding miRNA biogenesis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, RNA Synthesis, RNASynthesis, TRBP

Compound Identifiers

PubChem CID

20064063