Single Domain Antibodies

Single domain antibodies (sdAb), also called nanobodies, are the variable regions from the antigen-binding variable domains (VHH) of camel heavy-chain only antibodies, or the variable domains (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 15 kDa (2~4 nm), sdAbs are the smallest antigen-binding fragments available.

Due to their small size, sdAbs offer the following advantages compared with standard antibodies :

• Optimal affinity and specificity

• Highly stable over a wide range of pHs and temperatures

• Highly soluble

• Recognise hidden epitopes.

In addition to catalogue products, we can also offer custom services for single domain antibodies, including :

• Single-domain antibody libraries (immunized and naïve)

• Humanization

• Conjugation

• Multi-specific Antibody Development.