Single Domain Antibodies

Single domain antibodies (sdAb), also called nanobodies, are the variable regions from the antigen-binding variable domains (VHH) of camel heavy-chain only antibodies, or the variable domains (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 15 kDa (2~4 nm), sdAbs are the smallest antigen-binding fragments available.

Due to their small size, sdAbs offer the following advantages compared with standard antibodies :

  • Optimal affinity and specificity

  • Highly stable over a wide range of pHs and temperatures

  • Highly soluble

  • Recognise hidden epitopes.

In addition to catalogue products, we can also offer custom services for single domain antibodies, including :

  • Single-domain antibody libraries (immunized and naïve)

  • Humanization

  • Conjugation

  • Multi-specific Antibody Development.

Items 1-10 of 11

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  1. Anti-VIM VHH antibody [orb1562795]

    ELISA, WB

    Human

    Camelus

    250 μg
  2. 3 images
    • Chromatography analysis of recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) proteinusing antibody
    • Immunohistochemical analysis of paraffin-embedded human hepatoma tissue slides using anti-PCSK9 VHH
antibody
    • Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells stained with anti-PCSK9 VHH antibody
    anti-PCSK9 VHH antibody [orb1562796]

    ICC, IF, IHC-P

    Human

    Camelus

    250 μg
  3. 2 images
    • Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of 
anti-mCherry VHH antibody
    • Western blot analysis of 293T cell lysates using anti-mCherry VHH antibody
    anti-mCherry VHH antibody [orb1562797]

    ELISA, WB

    Coral

    Camelus

    250 μg
  4. 2 images
    • Western blot analysis of Lysate of U87-MG cell line using anti-GFAP VHH antibody
    • Immunohistochemical analysis of paraffin-embedded mouse brain tissue slides using anti-GFAP VHH antibody
    anti-GFAP VHH antibody [orb1562798]

    IHC-P, WB

    Human

    Camelus

    250 μg
  5. 2 images
    • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue slides using anti-EGFR
VHH antibody
    • Immunofluorescence analysis of paraformaldehyde fixed MCF-7 cells stained with anti-EGFR VHH antibody
    anti-EGFR VHH antibody [orb1562799]

    ICC, IF, IHC-P

    Human

    Camelus

    250 μg
  6. 2 images
    • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue slides using anti-HER2
VHH antibody
    • Immunofluorescence analysis of paraformaldehyde fixed MCF-7 cells stained with anti-HER2 VHH antibody
    anti-Her2 VHH antibody [orb1562800]

    ICC, IF, IHC-P

    Human

    Camelus

    250 μg
  7. 2 images
    • Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of 
anti-SARS-CoV-2 spike RBD VHH antibody.
    • Chromatography analysis of recombinant SARS-CoV-2 (2019-nCoV) Spike RBD protein using antibody
    anti-SARS-CoV-2 spike RBD VHH antibody [orb1562801]

    ELISA

    Virus

    Camelus

    250 μg
  8. 4 images
    • Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of 
anti-hTNFR1 VHH antibody.
    • Western blot analysis of human hepatocellular carcinoma tissue and A549 cells using anti-TNFR1 VHH antibody.
    • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-TNFR1
VHH antibody
    • Immunofluorescence analysis of paraformaldehyde fixed MCF-7 cells stained with anti-TNFR1 VHH antibody.
    anti-hTNFR1 VHH antibody [orb1562802]

    ELISA, ICC, IF, IHC-P, WB

    Human

    Camelus

    250 μg
  9. 5 images
    • Line graph illustrates about the Ag-Ab reactions using different concentrations of antigen and serial dilutions of 
anti-PD-L1 VHH antibody.
    • Chromatography analysis of human PD-L1 using antibody
    • Western blot analysis of Lysates of PLC cells using anti-PD-L1 VHH antibody.
    • Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue and human lung cancer tissue slides
using anti-PD-L1 VHH antibody
    • Immunofluorescence analysis of paraformaldehyde fixed MCF-7 cells stained with anti-PD-L1 VHH antibody
    anti-PD-L1 VHH antibody [orb1562803]

    ELISA, ICC, IF, IHC-P, WB

    Human

    Camelus

    250 μg
  10. anti-GFP VHH antibody, biotinylated [orb1562804]

    ELISA, ICC, IF, IHC-P

    Jellyfish

    Camelus

    250 μg

Items 1-10 of 11

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