Single Domain Antibodies
Single domain antibodies (sdAb), also called nanobodies, are the variable regions from the antigen-binding variable domains (VHH) of camel heavy-chain only antibodies, or the variable domains (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 15 kDa (2~4 nm), sdAbs are the smallest antigen-binding fragments available.
Due to their small size, sdAbs offer the following advantages compared with standard antibodies :
-
Optimal affinity and specificity
-
Highly stable over a wide range of pHs and temperatures
-
Highly soluble
-
Recognise hidden epitopes.
In addition to catalogue products, we can also offer custom services for single domain antibodies, including :
-
Single-domain antibody libraries (immunized and naïve)
-
Humanization
-
Conjugation
-
Multi-specific Antibody Development.