Angiotensin II human

SKU: orb2693938

Description

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: Angiotensin Receptor; Apoptosis
• CAS Number: 4474-91-3
• MW: 1046.19
• Purity: ≥95%
• Formula: C₅₀H₇₁N₁₃O₁₂
• Protein Sequence: DRVYIHPF

Storage & Handling

• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Angiotensin Receptor; Apoptosis