Alliin

SKU: orb1220704

Description

Alliin is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI.

Key Properties

• CAS Number: 556-27-4
• MW: 177.22
• Purity: >98% (HPLC)
• Formula: C₆H₁₁NO₃S
• SMILES: N[C@@H](CS(=O)CC=C)C(O)=O
• Target: PPAR
• Solubility: DMSO:3 mg/mL (16.92 mM)

Bioactivity

• In Vivo:
  Animal model: DSS colitis mouse model. Dosage: 500 mg/kg. Administration: i. g. , 10 days. Result: Decrease hematochezia symptom and diarrhea symptom. Improved weight loss. Reduced colon injury and inflammatory cell infiltration, restored the structure of colon epithelial and crypt. Reduced the expression of iNOS, TNF-α and IL-6 mRNAs.
• In Vitro:
  Cell Viability Assay Cell line: HepG2 cells. Concentration: 10-1280 μM. Incubation time: 24 h. Result: Decreased the cell viability at concentrations from 320 μM to 1280 μM. Did not have cell toxicity at concentrations from 0 μM to 160 μM. Western blot analysis. Cell line: HepG2 cells. Concentration: 0-160 μM. Incubation time: 23 h. Result: Increased the expression of p-AMPK and decreased the protein expression of AMPK at concentrations of 80 μM and 160 μM. Inhibited the protein expression of SREBP-1, FAS, SREBP-2 and HMGCR by 1, 3-DCP-induced at concentrations of 80 μM and 160 μM. Western blot analysis. Cell line: RAW264.7 Concentration: 100 μg/mL. Incubation time: 6 h. Result: Inhibited the protein expression ofiNOS, IL-1β, IL-6, and TNF-α, and the production of NO. Suppressed the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNAs. Blocked JNK/ERK1/2-mediated transcriptional activation of PPARγ.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-3-(Allylsulphinyl)-L-alanine

Quick Database Links

Gene Symbol

PPAR