AI-10-47

SKU: orb1298444

Description

AI-10-47 is a potent small molecule inhibitor that disrupts the interaction between CBFβ and RUNX transcription factors, exhibiting an IC50 of 3.2 µM. This compound serves as a valuable chemical probe for researching RUNX-dependent pathways in cancer and hematopoiesis, applicable in both cellular and biochemical assays.

Key Properties

• CAS Number: 1256094-31-1
• MW: 279.22
• Purity: 98.51% (May vary between batches)
• Formula: C₁₃H₈F₃N₃O
• SMILES: FC(F)(F)Oc1ccc2nc([nH]c2c1)-c1ccccn1
• Target: Others
• Solubility: DMSO:100 mg/mL (358.14 mM)

Bioactivity

• Target IC50:
  CBFβ-RUNX binding:3.2 μM
• In Vitro:
  AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growt;AI-10-47 with 10 μM weakly inhibits CBFβ-RUNX binding.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AI 10 47, AI1047, AI-10-47, 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47, CBFβ, CBFβ-RUNX binding, leukemia, ME-1, M0-91, RUNX, THP-1, TUR, U937

Compound Identifiers

PubChem CID

49804932