AI-10-47

SKU: orb1218985

Description

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

Key Properties

• CAS Number: 1256094-31-1
• MW: 279.22
• Purity: >98% (HPLC)
• Formula: C₁₃H₈F₃N₃O
• SMILES: FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
• Target: CBFβ-RUNX binding
• Solubility: DMSO:100 mg/mL (358.14 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding. AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth. Western blot analysis. Cell line: 4 x 106 SEM cells. Concentration: 10 μM. Incubation time: 6 h. Result: Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47

Quick Database Links

Gene Symbol

CBFβ-RUNX binding