AH-7614

SKU: orb1306116

Description

AH-7614 is a potent and selective antagonist of the free fatty acid receptor 4 (FFA4/GPR120). This small molecule is a valuable research tool for investigating the role of FFA4 in metabolic and inflammatory processes, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6326-06-3
• MW: 351.42
• Purity: 99.91%
• Formula: C₂₀H₁₇NO₃S
• SMILES: Cc1ccc(cc1)S(=O)(=O)NC1c2ccccc2Oc2ccccc12
• Target: GPCR
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.11 mM);DMSO:50 mg/mL (142.28 mM);H2O:Insoluble;Ethanol:Insoluble

Bioactivity

• In Vitro:
  AH7614 (0.063, 0.25, and 1μM) blocked linoleic acid and GSK137647A-induced intracellular calcium increase in U2OS osteosarcoma cells expressing the FFA4 receptor. In addition, the increase of glucose-stimulated insulin secretion by GSK137647A (50 μM) was abolished in the presence of the selective FFA4 antagonist AH7614 (100 μM) in the MIN6 mouse insulinoma cell line. Moreover, AH7614 (100 μM) blocked GSK137647A (100μM)-mediated a modest increase of GLP-1 secretion in the NCIH716 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FFA4, FFAR, GPR120, Free Fatty Acid Receptor, inhibit, linoleic, negative, NAM, acid, allosteric, AH7614, AH-7614, AH 7614

Compound Identifiers

PubChem CID

233085