AH-7614

SKU: orb1306116

Description

AH-7614 is a potent and selective antagonist of the free fatty acid receptor 4 (FFA4/GPR120). This small molecule is a valuable research tool for investigating the role of FFA4 in metabolic and inflammatory processes, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6326-06-3
• MW: 351.42
• Purity: 99.91%
• Formula: C₂₀H₁₇NO₃S
• SMILES: Cc1ccc(cc1)S(=O)(=O)NC1c2ccccc2Oc2ccccc12
• Target: GPCR
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.11 mM);DMSO:50 mg/mL (142.28 mM);H2O:Insoluble;Ethanol:Insoluble

Bioactivity

• In Vitro:
  AH7614 (0.063, 0.25, and μM) blocked linoleic acid and GSK137647A-induced intracellular calcium increase in U2OS osteosarcoma cells expressin the FFA4 receptor. In addition the increase of glucose-stimulated Insulin secretion by GSK137647A 50 μM) was abolished in the presence o the Selective FFA4 antagonist AH7614 (100 μM) in the MIN6 mouse insulinoma cell line. Moreover, AH7614 (100 μM) blocked GSK137647A (10 μM)-mediated a modest increase of GLP-1 secretion in the NCIH716 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FFA4, FFAR, GPR120, Free Fatty Acid Receptor, inhibit, linoleic, negative, NAM, acid, allosteric, AH7614, AH-7614, AH 7614

Compound Identifiers

PubChem CID

233085