AH 7614

SKU: orb1217792

Description

AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

Key Properties

• CAS Number: 6326-06-3
• MW: 351.42
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₇NO₃S
• SMILES: O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
• Target: GPR
• Solubility: DMSO:35.1 mg/mL(100 mM);Ethanol:Insoluble;Water:Insoluble

Bioactivity

• In Vivo:
  AH7614 (50μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice. AH7614 (50μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.
• In Vitro:
  AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells. AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells. AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50= 7.70). AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPR