Agnuside

SKU: orb1303636

Description

Agnuside

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 11027-63-7
• MW: 466.44
• Purity: 99.08%
• Formula: C₂₂H₂₆O₁₁
• SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Prostaglandin Receptor,HIF/HIF Prolyl-Hydroxylase,NO Synthase,COX,ASCT,Caspase,P-gp
• Solubility: DMSO:50 mg/mL (107.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.29 mM)

Bioactivity

• Target IC50:
  COX-2:0.026 mg/mL
• In Vivo:
  Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4
• In Vitro:
  Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Agnoside, Agnuside, COX-2, chasteberry oil, inhibit, Inhibitor, Prostaglandin Receptor, ProstaglandinReceptor, Pgp, P-gp (P-glycoprotein)

Compound Identifiers

PubChem CID

442416