Agnuside

SKU: orb1221234

Description

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3 66.8 and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5 25 and 100 μM respectively.

Key Properties

• CAS Number: 11027-63-7
• MW: 466.44
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₆O₁₁
• SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O
• Target: COX
• Solubility: DMSO: 10 mg/mL

Bioactivity

• In Vivo:
  Animal model: Balb/C female mice model. Dosage: 30 mg/kg, 60 mg/kg. Administration: Oral gavage (p.o.); Single dose. Result: Decreased the expression of LC3B and increased the expression of Beclin1/p62 (LC3B and Beclin1/p62 are autophagy markers). Decreased the levels of IgE and IL-4/ IL-10 in a dose-dependent manner. (IgE and IL-4/ IL-10 are allergic inflammatory mediators). Animal model: KAO rat model. Dosage: 6.25 mg Monosodium iodoacetate (MIA): 1 mg. Administration: Oral gavage (p.o.); Single dose. Result: Alleviated the degree of local hypoxia in the synovial tissue of rats and significantly reduced the level of pro-fibrotic substances in the synovial tissue. Inhibited the accumulation of HIF-1α and activation of NLRP3 inflammasome.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

chasteberry oil

Quick Database Links

Gene Symbol

COX