AGN 196996

SKU: orb2901838

Description

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Key Properties

• CAS Number: 958295-17-5
• MW: 482.32
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₀BrNO₅
• SMILES: CCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Autophagy
• Solubility: In Vitro: DMSO : 250 mg/mL (518.33 mM; Ultrasonic )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy