AGN 196996

SKU: orb1710476

Description

AGN 196996 is a highly potent and selective RARα antagonist with a Ki of 2 nM, demonstrating minimal activity at RARβ and RARγ. This selectivity makes it a valuable chemical probe for investigating RARα-specific signaling in retinoid research, applicable in both cellular and animal models of differentiation and disease.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 958295-17-5
• MW: 482.32
• Purity: 99.94%
• Formula: C₂₄H₂₀BrNO₅
• SMILES: CCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Autophagy,Retinoid Receptor
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (6.84 mM);DMSO:225 mg/mL (466.5 mM)

Bioactivity

• Target IC50:
  RARβ:1087 nM(Ki)|RARγ:8523 nM(Ki)|RARα:2 nM(Ki)
• In Vitro:
  AGN 196996 is a potent and selective RARα antagonist with a Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). RARα antagonist AGN 196996 shows no activity in transactivation assays but instead blocks the gene transcriptional activity induced by ATRA and other RAR agonists.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, AGN196996, AGN-196996, AGN 196996, RARα, RARβ, RARγ, Retinoid Receptor, RetinoidReceptor

Compound Identifiers

PubChem CID

24785198