AGK2

SKU: orb1300826

Description

AGK2

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 304896-28-4
• MW: 434.27
• Purity: 99.17% (May vary between batches)
• Formula: C₂₃H₁₃Cl₂N₃O₂
• SMILES: Clc1ccc(Cl)c(c1)-c1ccc(C=C(C#N)C(=O)Nc2cccc3ncccc23)o1
• Target: Sirtuin|||Apoptosis
• Solubility: DMSO:4.95 mg/mL (11.4 mM)

Bioactivity

• Target IC50:
  SIRT2:3.5 μM|SIRT3:91 μM|SIRT1:30 μM
• In Vivo:
  In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation.
• In Vitro:
  In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AGK 2, AGK2, AGK-2, Apoptosis, Inhibitor, inhibit, Sirtuin, SIRT2

Compound Identifiers

PubChem CID

1183107