AGB1

SKU: orb1785999

Description

AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM.

Key Properties

• CAS Number: 2776190-62-4
• MW: 1031.68
• Purity: >97%
• Formula: C₅₁H₆₃ClN₈O₉S₂
• SMILES: ClC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(C)S4)C)[C@@H](CC)C(OCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C=C6)C7=C(C)N=CS7)=O)=O)=O)=O

Storage & Handling

• Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Chemical Structure: 2776190-62-4

Compound Identifiers

PubChem CID

162641704