Adenosine

SKU: orb1310233

Description

Adenosine is a naturally occurring ribonucleoside composed of adenine and ribose. It exhibits vasodilatory, antiarrhythmic, and analgesic properties, making it a key molecule for cardiovascular and neurological research in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58-61-7
• MW: 267.24
• Purity: 99.92% (May vary between batches)
• Formula: C₁₀H₁₃N₅O₄
• SMILES: NC1=NC=NC2=C1N=CN2C1OC(CO)C(O)C1O
• Target: Endogenous Metabolite|||Nucleoside Antimetabolite/Analog|||Apoptosis|||Autophagy
• Solubility: 5% DMSO+95% Saline:1.05 mg/mL (3.93 mM);DMSO:166.6 mg/mL (623.41 mM);H2O:2.7 mg/mL (10.1 mM);10% DMSO+90% Saline:2 mg/mL (7.48 mM)

Bioactivity

• Target IC50:
  KKU-213 cells:320 μM|KKU-055 cells:1000 μM|RMCCA-1 cells:255 μM|HuCCA1 cells:270 μM
• In Vivo:
  METHODS: To investigate the antidepressant-like effects, Adenosine (1-10 mg/kg) was intraperitoneally injected into mice and subjected to the forced swimming test (FST) and tail suspension test (TST). RESULTS: The immobilization time in the FST was shortened by intraperitoneal injection of Adenosine (5-10 mg/kg), and Adenosine (1-10 mg/kg) also produced antidepressant-like effects in the TST.
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• In Vitro:
  METHODS: Human prostate cancer cells DU-145, PC3 and LNcap-FGC-10 were treated with Adenosine (0.1-1000 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Adenosine significantly reduced cell proliferation of DU-145, PC3 and LNcap-FGC10 cell lines in a dose-dependent manner. METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Adenosine (2 mM) for 6-24 h. The cell cycle was detected by Flow cytometry. RESULTS: Adenosine-induced inhibition of survival was attributed to the arrest of cell cycle progression. Adenosine significantly increased the percentage of G0/G1-phase cells and decreased the percentage of S-phase and G2/M-phase cells in HepG2 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adenosine, Adenine riboside, aggregation, blood, Autophagy, Apoptosis, Analog, D-Adenosine, Endogenous Metabolite, cell, inhibit, neuronal, Nucleoside Antimetabolite, Nucleoside, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, EndogenousMetabolite, endogenous, GPCR, Inhibitor, platelet, regulation, vascular

Compound Identifiers

PubChem CID

191