Ac-CoA Synthase Inhibitor1

SKU: orb1222151

Description

MDK-6149, also known as ACSS2 Inhibitor or Ac-CoA Synthase Inhibitor I, is a Ac-CoA Synthase Inhibitor. MDK-6149 has CAS#508186-14-9. It was first reported in 2014. Cell. 159, 1591. For the convenience of scientific communication, we temporally name it as MDK-6149. The last 4 digit of its CAS# was used for name.

Research Area

Metabolism Research

Key Properties

• CAS Number: 508186-14-9
• MW: 410.51
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈N₄O₂S₂
• SMILES: COCCNC(=O)Nc2cc3nc(c1cccs1)c(nc3cc2)c4cccs4
• Target: IκB kinase (IKK)
• Solubility: DMSO : ≥ 100 mg/mL; 243.60 mM

Bioactivity

• In Vitro:
  Ac-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 μM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ac-CoA Synthase Inhibitor I | MDK6149 | ACSS2 Inhibitor

Quick Database Links

Gene Symbol

IκB kinase (IKK)